Appendix, solitary and intestinal lymph follicles, mucous
lymphocytes make a cluster of gut- associated lymph tissue
called GALT. Alimentary tract lymphocytes provide two
basic tasks; they produce Ig A being the first defence line
against pathogenic micro-organisms and regulate processes
of immunologic response to antigens reaching its lumen. To
recognize GALT structure and its function better, the
experimental study on 21 sexually mature male rats of Wistar
strain was carried out. The animals were divided into 2
study groups A and B each consisting of 7 rats and 1 control
K consisting of 7 rats. The rats from one study group A had
an appendectomy and the rats from the other group B had
ileocolic lymph nodes removed. The rats from the control
group K underwent only laparotomy. After 63 days, the
respective organs were taken and the animals were
sacrificed. The appendices and ileocolic lymph nodes
functioning for 63 days in the anatomically changed
conditions underwent macro- and microscopic examination
and were compared wih the image of the control group
organs. No significant morphologic differences were found.
Additionally, immunohistochemical examination was
carried out with specific antibodies Mous Anti Rat CD 45
RA aimed against all B lymphocytes and Mous Anti Rat CD
43 aimed against all T lymphocytes and the evaluation of
the immunohistochemical reaction intensity was done with
the use of a computer image analyzer. A decreased average
number of B lymphocytes was found in the ileocolic lymph
node parenchyma of the experiment animals; mean number
of T lymphocytes was on the same level. The quantitative
ration of B lymphocytes to T lymphocytes changed. Similar
immunologic changes can be present in other immune system
organs; therefore, it seems necessary to continue the
experiments and study.
Key words: GALT (gut associated lymphoid tissue), immune
system, appendectomy, lymph nodes, lymphology

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